Signaling by Neuronal Swelling

Glial-neuronal signaling and astroglial swelling in physiology and pathology.

Swelling and death of neuronal cells by lactic acid.

Lactacidosis occurring in cerebral ischemia or trauma is a major mechanism of cytotoxic brain edema and brain damage. Respective effects of lactacidosis were currently analyzed in vitro by employment of the murine neuronal cell line, Neuro-2A, in order to obtain a better understanding of specific mechanisms underlying cell swelling and cell death in comparison with glial cells. The cells were s...

Mechanisms of Neuronal Swelling during Spreading Depolarization

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The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular Cl(-) that is required for neuronal swelling and death. Pharmacological and si...

Neuronal Calcium Signaling Review

the two membranes are bound together (Rosenbluth, Introduction 1962). Indeed, the two membranes are separated by a Calcium plays an important role in regulating a great fuzzy material with a distinct periodicity reminiscent of variety of neuronal processes. Like other cells, neurons the triadic junction of muscle cells (Henkart et al., 1976). use both extracellular and intracellular sources of ...